LymphedemaV1, Main, Exploration, bibRecord, 007F17

Pharmacogenomics: its role in re-establishing coumarin as treatment for lymphedema.

Identifieur interne : 007F17 ( Main/Exploration ); précédent : 007F16; suivant : 007F18

Pharmacogenomics: its role in re-establishing coumarin as treatment for lymphedema.

Auteurs : Nicholas Farinola [Australie] ; Neil Piller

Source :

Lymphatic research and biology [ 1539-6851 ] ; 2005.

RBID : pubmed:16000056

Descripteurs français

KwdFr :
- Aryl hydrocarbon hydroxylases (génétique), Coumarines (effets indésirables), Coumarines (pharmacologie), Coumarines (usage thérapeutique), Cytochrome P-450 CYP2A6, Flavonoïdes (pharmacologie), Humains, Lymphoedème (génétique), Lymphoedème (traitement médicamenteux), Mixed function oxygenases (génétique), Pharmacogénétique, Polymorphisme de nucléotide simple.
MESH :
- effets indésirables : Coumarines.
- génétique : Aryl hydrocarbon hydroxylases, Lymphoedème, Mixed function oxygenases.
- pharmacologie : Coumarines, Flavonoïdes.
- traitement médicamenteux : Lymphoedème.
- usage thérapeutique : Coumarines.
- Cytochrome P-450 CYP2A6, Humains, Pharmacogénétique, Polymorphisme de nucléotide simple.

English descriptors

KwdEn :
- Aryl Hydrocarbon Hydroxylases (genetics), Coumarins (adverse effects), Coumarins (pharmacology), Coumarins (therapeutic use), Cytochrome P-450 CYP2A6, Flavonoids (pharmacology), Humans, Lymphedema (drug therapy), Lymphedema (genetics), Mixed Function Oxygenases (genetics), Pharmacogenetics, Polymorphism, Single Nucleotide.
MESH :
- chemical , adverse effects : Coumarins.
- chemical , genetics : Aryl Hydrocarbon Hydroxylases, Mixed Function Oxygenases.
- chemical , pharmacology : Coumarins, Flavonoids.
- chemical , therapeutic use : Coumarins.
- chemical : Cytochrome P-450 CYP2A6.
- drug therapy : Lymphedema.
- genetics : Lymphedema.
- Humans, Pharmacogenetics, Polymorphism, Single Nucleotide.

Abstract

Although there remains some significant controversy regarding the use and benefits of coumarin (5,6-benzo-alpha pyrone), it would seem that targeted appropriate and monitored use of the drug does have a significant role in the treatment of lymphedemas. The particular benefits are its cost and ease of administration. Given today's demands for high level investigative clinical trials, it would be virtually impossible to conduct a study large enough to make any significant conclusions about hepatotoxic effects. However, it seems without doubt that the majority of studies conducted thus far suggest that coumarin (and other benzopyrones, i.e., the ruto-sides, which do not have hepatotoxic effects and which are often discussed in aggregate with coumarin) is effective in treating lymphedema, particularly when used in conjunction with complex physical therapy. The use of pharmacogenomics could significantly lower the risk of coumarin-associated hepatotoxicity, by targeting the use of coumarin to those with functional CYP2A6. Further research in this area will be required to re-evaluate the cost- benefit ratio and to determine the potential for the reintroduction of coumarin as a potent treatment for lymphedema. The perceived negative image of coumarin should not be allowed to carry across to the other benzopyrones, as they still confer a significant benefit in the management of lymphedemas.

DOI: 10.1089/lrb.2005.3.81
PubMed: 16000056

Affiliations:

Le document en format XML

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<term>Lymphoedème (génétique)</term>
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<front><div type="abstract" xml:lang="en">Although there remains some significant controversy regarding the use and benefits of coumarin (5,6-benzo-alpha pyrone), it would seem that targeted appropriate and monitored use of the drug does have a significant role in the treatment of lymphedemas. The particular benefits are its cost and ease of administration. Given today's demands for high level investigative clinical trials, it would be virtually impossible to conduct a study large enough to make any significant conclusions about hepatotoxic effects. However, it seems without doubt that the majority of studies conducted thus far suggest that coumarin (and other benzopyrones, i.e., the ruto-sides, which do not have hepatotoxic effects and which are often discussed in aggregate with coumarin) is effective in treating lymphedema, particularly when used in conjunction with complex physical therapy. The use of pharmacogenomics could significantly lower the risk of coumarin-associated hepatotoxicity, by targeting the use of coumarin to those with functional CYP2A6. Further research in this area will be required to re-evaluate the cost- benefit ratio and to determine the potential for the reintroduction of coumarin as a potent treatment for lymphedema. The perceived negative image of coumarin should not be allowed to carry across to the other benzopyrones, as they still confer a significant benefit in the management of lymphedemas.</div>
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Pharmacogenomics: its role in re-establishing coumarin as treatment for lymphedema.

Pharmacogenomics: its role in re-establishing coumarin as treatment for lymphedema.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

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